Endocrine Abstracts

Introduction: Pituitary adenomas are considered to be benign tumors that are diagnosed by its sympthoms (secondary to compression or hormonal secretion) or incidentally in an imaging technique performed because of another reason. ‘Silent’ somatotrophinomas are very rare. This type of adenoma is typically large and despite it presents with mild or no acromegalic features it usually develops hormone secretion.A case report: A 29-year-old spanish ...

Introduction: In most patients with familial history of pheochromocytoma/paraganglioma, leads in the majorty of cases to a postive genetic testing for mutations, and what’s more in those patients with no familial antecedents, about 10–25% carry a mutation in one related gene. In these cases other aspects like, bilaterality, multiplicity or location must be taken into account.Objective: The objective of the study was to discuss the importance of...

Introduction: Prolactinomas are the most common tumors among functional pituitary adenomas and they constitute 40% of all pituitary tumors. Dopamine agonists (DA) are considered the primary treatment of prolactinoma. DA can lead to complete remission (including eradicacion of the tumor), allowing discotinuation of treatment. So far, there aren’t clinical criteria with sufficient predictive value for long-term remission.Objective: To assess the effec...

Background and objective: The incidence of differentiated thyroid carcinoma (DTC) is increasing worldwide. Due to a increased use of improved radiological techniques, especially ultrasound. This study aims to analyze histological characteristics of DTC diagnosed in our hospital in the last fifteen years.Patients and methods: It is a restrospective descriptive study. We have included all operated patients in our center between 2001 and 2015 with a final b...

Introduction: The association of bullous pemphigoid (BP) with the use of dipeptidyl-peptidase 4 (DPP-4) inhibitors among patients with diabetes has recently emerged. The risk of developing BP during treatment with new DPP-4 inhibitor agents like linagliptin is yet to be established. The clinical features and the prognostic outcomes of patients with DPP-4 inhibitor-associated BP are yet to be established.Objective: To report a case of BP on a patient with...

Introduction: The most common cause of hyponatraemia is the syndrome of inappropriate antidiuretic hormone (SIADH). The diagnosis typically requires hyponatraemia in the setting of reduced serum osmolality, inappropriately concentrated urine with normal sodium excretion levels, and the absence of interfering medications, hypothyroidism and adrenal insufficiency. Unless hypertonic saline is indicated for acute onset profound hyponatraemia and/or with severe symptoms, the mainst...

Introduction: TKIs including anti-VEGF receptor activity have been approved for the treatment of patients with radioiodine resistant thyroid carcinomas. For lenvatinib arterial thromboembolic events are listed as adverse events of special interest. In the phase III study of SELECT trial, arterial thromboembolic events were reported in 3% of lenvatinib-treated patients and 1% in the placebo group. Most of the patients had predisposing factors. Only one myocardial infarct was re...

Introduction: Osmotic demyelination syndrome (ODS) is a well described, potentially devastating consequence of rapid alterations in plasma osmolality, classically occurring secondary to the excessively rapid correction of chronic hyponatraemia. We describe a case of diabetes insipidus (DI) resulting in a Locked-in syndrome (LIS) caused by a rapidly developing severe hypernatremia.Case report: A 43-year-old woman was admitted to the Internal Medicine ward...